Thank you for your questions.
With respect to Question 1):
Yes, there is no limitation, more information can be found in the <a href="https://register.ema.europa.eu/identityiq/help/useradmin.html">User Administrator Guide · EMA Account Management (europa.eu)</a>.<br>
As regards Question 2):<br> - the same User can request his/her access to be removed: <a href="https://register.ema.europa.eu/identityiq/help/requestaccess.html#removeaccess">Request Access · EMA Account Management (europa.eu)</a><br> - or another User Admin can remove the access of the administrator that left the company using the IRIS Role Admin tab in EMA Account Management, more information can be found in the <a href="https://register.ema.europa.eu/identityiq/help/useradmin.html#useradminremoveaccess">User Administrator Guide · EMA Account Management (europa.eu)</a><br> <br> In general, <a href="https://register.ema.europa.eu/identityiq/home.html">Home · EMA Account Management (europa.eu)</a> offers documentation on how to manage users and roles at EMA.<br>