Submission of documents exceeding size limit of 50 Mb in IRIS

I was wondering if there is any guidance on how to handle larger documents such as a clinical study report being submitted as part of PIP compliance check? These document are typically much larger than the size limit of 50 Mb.
 

The IRIS system by default limits the size of individual files uploaded as part of an application to 50 Mb. Almost all text and PDF files can be reduced to a size within this limit through the use of appropriate techniques, some of which are reported below. Zip files should not be used, except for references (which can also, preferably, be sent as a single combined PDF file). 

For Word Documents:

1. Compress Images:

   • Go to File > Options > Advanced.
   • Scroll down to the "Image Size and Quality" section.
   • Uncheck the box for "Do not compress images in file" and select a lower resolution, such as 150ppi, in the field below.
      

2. Save As Different Format:

   • Save the document as a .docx file instead of .doc. The .docx format is more efficient in terms of file size.
      

3. Remove Unused Styles and Formatting:

   • Go to Home > Styles.
   • Clean up unused styles by right-clicking and deleting them.
      

4. Embed Fonts Efficiently:

   • Go to File > Options > Save.
   • Under "Preserve fidelity when sharing this document," check the box for "Embed fonts in the file" but uncheck "Embed all characters" and "Do not embed common system fonts."

For PDF Documents:

1. Optimize PDF Using Adobe Acrobat:

   • Open the PDF in Adobe Acrobat Pro.
   • Go to File > Save As Other > Optimized PDF.
   • Use the settings to compress images, discard unnecessary objects, and streamline the document structure.
      

2. Reduce PDF Size Online:

   • Use online tools like Smallpdf, ILovePDF, or PDF Compressor to reduce file size.
      

3. Save As Reduced Size PDF:

   • Open the PDF in Adobe Acrobat.
   • Go to File > Save As Other > Reduced Size PDF.
      

4. Remove Unnecessary Objects:

   • Use the "Edit PDF" tool in Adobe Acrobat to remove any unnecessary images, text, or other objects.

Additional Tips for Both Formats:

• Remove Metadata: Removing metadata and document properties can reduce file size.
• Use External Tools: Use tools like Microsoft Word's "Compress Media" feature for videos or third-party software designed for file compression.
• Split Document: If the document is still too large, consider splitting it into multiple smaller documents.