In principle it should be possible to overwrite an existing uploaded file in an IRIS submission, simply by re-uploading a file with the exact same name and extension. Of course, to do that the submission must have been (temporarily) reopened by EMA staff: submissions are normally locked during the evaluation process. If reuploading with the same name fails for any reason, it is always possible to upload an updated version of the same file, with a suitable name, but this should not be needed.