A specific feature to allow downloading the substance list is currently not implemented in IRIS. This will be possible via the SMS API, once SMS (the master data for the IRIS substance list) is fully included in SPOR. EMA is working on an export of public substance data into a static list (CSV) to be published on the SPOR portal landing page for SMS. This is expected to be in place by end 2021.
The export of the full details of the substance list (Human and Vet) will be possible via the SPOR API in 2022 once security is in place. For more information about SPOR timelines, you can submit an enquiry via Ask EMA.